منابع مشابه
Direct Inhibition of TNF-α Promoter Activity by Fanconi Anemia Protein FANCD2
Fanconi anemia (FA), an inherited disease, is associated with progressive bone marrow failure, predisposition to cancer, and genomic instability. Genes corresponding to 15 identified FA complementation groups have been cloned, and each gene product functions in the response to DNA damage induced by cross-linking agents and/or in protection against genome instability. Interestingly, overproducti...
متن کاملTLR8-dependent TNF- overexpression in Fanconi anemia group C cells
1Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland; 2Department of Pediatric Hematology/Oncology, Ospedale Gaslini, Genoa, Italy; Departments of 3Molecular and Medical Genetics and 4Medicine, Oregon Health & Science University, Portland; 5NW Veterans Affairs (VA) Cancer Research Center, Portland VA Medical Center, OR; 6Department of Physiology and Ph...
متن کاملFrequency of Hypothyroidism in Fanconi Anemia
Background: Fanconi anemia (FA) is a rare, autosomal recessive (AR) and multifactorial disorder. A high prevalence of FA observed in Iran is perhaps due to the high rate of consanguineous marriages. This study investigates the extent of short stature in patients with FA, the frequency of hypothyroidism in FA and the correlation between height and hypothyroidism. Methods: Eighteen patients with ...
متن کاملMutated Fanconi anemia pathway in non-Fanconi anemia cancers
An extremely high cancer incidence and the hypersensitivity to DNA crosslinking agents associated with Fanconi Anemia (FA) have marked it to be a unique genetic model system to study human cancer etiology and treatment, which has emerged an intense area of investigation in cancer research. However, there is limited information about the relationship between the mutated FA pathway and the cancer...
متن کاملFanconi anemia
What is it? Fanconi anemia (FA) is an autosomal recessive human disease characterized by congenital malformations, bone marrow failure and cancer. FA patients often develop leukemia and/or squamous cell carcinomas of the head and neck or gynecologic system. FA cells are hypersensitive to DNA crosslinking agents, such as mitomycin C (MMC) or diepoxybutane (DEB), and the syndrome is believed to r...
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ژورنال
عنوان ژورنال: Blood Cells, Molecules, and Diseases
سال: 2014
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2013.06.005